Statement on the application of the CORROSITEX assay for skin corrosivity testing.
نویسنده
چکیده
منابع مشابه
Executive Summary: ICCVAM Review of In Vitro Dermal Corrosivity Methods
Corrosive substances are defined as chemicals causing visible destruction or irreversible alterations in living tissue by chemical action at the site of contact (29 CFR 1917.28). Dermal corrosivity testing is conducted to identify chemicals that potentially pose this hazard to humans. U.S. Federal regulations and guidelines include test methods for assessing dermal corrosivity. Testing data is ...
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Currently, the European Centre for the Validation of Alternative Methods (ECVAM) has supported formal validation studies on in vitro tests for predicting skin irritancy and corrosivity, which included three of the in vitro tests employed human skin models, EPISKINTM and EpiDermTM. When skin models are used to evaluate skin irritancy and corrosivity, it is important that suitable chemical applic...
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There have been several highly significant achievements in the area of alternatives for skin corrosivity testing in the last three years, most notably: (a) the validation, and subsequent endorsement, of two replacement alternative tests for skin corrosivity (the rat skin transcutaneous electrical resistance [TER] and EPISKINtrade mark human skin model assays) by the European Centre for the Vali...
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1. Skin corrosion refers to the production of irreversible damage to the skin, manifested as visible necrosis through the epidermis and into the dermis, following the application of a test material [as defined by the United Nations (UN) Globally Harmonized System of Classification and Labelling of Chemicals (GHS)] (1). This Test Guideline provides an in vitro procedure by which the assessment o...
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ورودعنوان ژورنال:
- Alternatives to laboratory animals : ATLA
دوره 29 2 شماره
صفحات -
تاریخ انتشار 2001